Nuclear receptor 4A2 - Wikipedia
WEBThe nuclear receptor 4A2 (NR4A2) (nuclear receptor subfamily 4 group A member 2) also known as nuclear receptor related 1 protein (NURR1) is a protein that in humans is encoded by the NR4A2 gene. [5] NR4A2 is a member of the nuclear receptor family of intracellular transcription factors.
NURR1 in Parkinson disease—from pathogenesis to therapeutic
WEBOct 15, 2013 · Orphan nuclear receptor NURR1 (NURR1, also known as NR4A2) is involved in the differentiation of midbrain DA neurons, but also has an important role in the adult brain.
The orphan nuclear receptor Nurr1 is responsive to non ... - Nature
WEBJul 3, 2020 · Nuclear receptor related 1 (Nurr1) is an orphan ligand-activated transcription factor and considered as neuroprotective transcriptional regulator with great potential as therapeutic target...
The role of NURR1 in metabolic abnormalities of Parkinson’s disease
WEBJun 27, 2022 · Nuclear receptor-related factor 1 (NURR1), an orphan member of the nuclear receptor superfamily of transcription factors, is a major risk factor in the pathogenesis of PD, and changes in NURR1 expression can have a detrimental effect on cellular metabolism.
An optimized Nurr1 agonist provides disease-modifying effects in ...
WEBJul 18, 2023 · The nuclear receptor, Nurr1, is critical for both the development and maintenance of midbrain dopamine neurons, representing a promising molecular target for Parkinson’s disease (PD).
Nurr1‐Based Therapies for Parkinson's Disease - PMC
WEBMar 25, 2016 · The pharmacological effects of Nurr1‐based therapies against PD are proposed as follows: (1) increase the expression of DA‐related genes; (2) protect or repair DA neurons against neurotoxins; (3) inhibit the microglia activation and suppress neuroinflammation.
Mechanisms of NURR1 Regulation: Consequences for Its …
WEBJul 31, 2023 · The dysregulation of NURR1 activity may play a role in various diseases, including the onset and progression of neurodegenerative diseases, and several other pathologies. NURR1 is regulated by multiple mechanisms, among which phosphorylation by kinases or SUMOylation are the best characterized.
Nurr1 in Parkinson’s disease and related disorders - PMC
WEBJan 1, 2006 · Nurr1, an orphan member of the nuclear receptor superfamily, is highly expressed in the developing and adult ventral midbrain and is required for the acquisition and maintenance of the dopaminergic phenotype in nigrostriatal neurons (Zetterstrom et al., 1997; Saucedo-Cardenas et al., 1998; Sacchetti et …
Nurr1, an orphan nuclear receptor with essential functions in ...
WEBSep 1, 2004 · Nurr1 is a transcription factor that is expressed in the embryonic ventral midbrain and is critical for the development of dopamine (DA) neurons. It belongs to the conserved family of nuclear receptors but lacks an identified ligand and is therefore referred to as an orphan receptor.
Covalent Modification and Regulation of the Nuclear Receptor Nurr1 …
WEBMay 16, 2019 · Nurr1, a nuclear receptor essential for the development, maintenance, and survival of midbrain dopaminergic neurons, is a potential therapeutic target for Parkinson's disease, a neurological disorder characterized by the degeneration of these same neurons.
Skip to content