Guelph is a city in Southwestern Ontario, Canada. Known as The Royal City, it is roughly 22 km east of Kitchener and 70 km west of Downto…Guelph is a city in Southwestern Ontario, Canada. Known as The Royal City, it is roughly 22 km east of Kitchener and 70 km west of Downtown Toronto, at the intersection of Highway 6, Highway 7 and Wellington County Road 124. It is the seat of Wellington County, but is politically independent of it.