Mitchell is a city in Marion Township, Lawrence County, Indiana, United States. The population was 4,350 at the 2010 census. Mitchell was built as a railroad town in the mid-19th century. At this location in Lawrence County, the Chicago, Indianapolis and Louisville Railroad, better known by the shorter name of "the Monon", was built as a north-south line from New Albany to Chicago, passing through the area which became Mitchell in 1853. In 1857, the east-west Ohio and Mississippi Railway was completed, as part of a link between Cincinnati and St. Louis.
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