With both fighters being deceptively difficult to kill, their first encounter back at UFC 297 ended up being a tactical, back-and-forth battle that saw Du Plessis narrowly scrape out a split decision win on the scorecards to become the new champion at 185 pounds.

This is the second title defense for the 31-year-old Du Plessis (22-2), a -210 favorite at BetMGM Sportsbook. He defeated Israel Adesanya with a fourth-round submission Aug. 17 in Perth, Australia.

There's a lot of opportunity for bettors when it comes to UFC 312. There are two title fights on the line which always add extra elements of drama and intrigue. But it's several fights on the prelims that have the biggest chance at large payouts.