MedPage Today

CellCept Succeeds in ANCA Vasculitis

Mycophenolate mofetil (CellCept) was as effective as cyclophosphamide for remission induction in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, Japanese researchers reported. In a ...
Healio

GPA, PR3-ANCA predictors of vasculitis relapse

DESTIN, Fla. — Practical, individualized care for patients with antineutrophil cytoplasmic antibody-associated vasculitis should use the presence of granulomatosis with polyangiitis, rather than ...
Medscape

Crescentic Glomerulonephritis Requiring Hemodialysis and Elevated MPO-ANCA Level and Vasculitis Allergica Cutis in a 21-Year-Old Girl

mPA can affect the gastrointestinal tract in 30% of cases and result in abdominal pain, diarrhea, and bleeding. Peripheral neuropathy occurs in about a third of patients. Myalgias and arthralgias are ...
Nature

Diagnostic significance of ANCA in vasculitis

Wegener's granulomatosis, microscopic polyangiitis (MPA), Churg–Strauss syndrome, and primary pauci-immune crescentic glomerulonephritis are associated with circulating anti-neutrophil cytoplasmic ...
Nature

Inducing remission in ANCA-positive vasculitis: time to RAVE?

Standard therapy for vasculitis associated with antineutrophil cytoplasmic antibodies can achieve high rates of remission, but with the risk of serious toxic effects. The results of a ...
FierceBiotech

ChemoCentryx Announces Positive Results in Phase II ANCA-Associated Vasculitis CLEAR Trial of Orally Administered Complement 5a Receptor Inhibitor CCX168

-- Primary endpoint achieved: CCX168 demonstrates numerical superiority and achieves statistical significance in test for non-inferiority in BVAS response relative to standard of care -- -- Treatment ...
News Medical

Researchers identify genetic basis for anti-neutrophil cytoplasmic antibody-associated vasculitis

Autoimmune disease is fundamentally a mystery: whyever should an organism systematically set out to harm itself? Now, researchers at the University of Tsukuba have identified a genetic basis for ...
FierceBiotech

ChemoCentryx Announces Positive Top-Line CCX168 Phase II Data in ANCA-Associated Renal Vasculitis

MOUNTAIN VIEW, Calif., Dec. 3, 2013 (GLOBE NEWSWIRE) -- ChemoCentryx, Inc., (Nasdaq:CCXI), today announced positive top-line data from the first two steps of a Phase II trial with CCX168, an inhibitor ...
Business Wire

VFMCRP and ChemoCentryx Announce Positive Topline Data From Pivotal Phase-III ADVOCATE Trial Demonstrating Avacopan’s Superiority Over Standard of Care in ANCA Associated ...

ST. GALLEN, Switzerland & MOUNTAIN VIEW, Calif.--(BUSINESS WIRE)--Regulatory News: Vifor Fresenius Medical Care Renal Pharma (VFMCRP) and ChemoCentryx, Inc., (NASDAQ:CCXI) today announced positive ...
Medscape

Crescentic Glomerulonephritis Requiring Hemodialysis and Elevated MPO-ANCA Level and Vasculitis Allergica Cutis in a 21-Year-Old Girl

In March 1998, the patient was a 19-year-old girl with a 10-day history of emesis, myalgia, arthralgia, and weight loss, who was found on routine physical examination to have edema in her face and ...
Nasdaq

ChemoCentryx and VFMCRP Announce Positive Topline Data from Pivotal Phase III ADVOCATE Trial Demonstrating Avacopan’s Superiority Over Standard of Care in ANCA-Associated ...

MOUNTAIN VIEW, Calif. and ST. GALLEN, CH, Nov. 25, 2019 (GLOBE NEWSWIRE) -- ChemoCentryx, Inc., (NASDAQ: CCXI) and Vifor Fresenius Medical Care Renal Pharma (VFMCRP) today announced positive topline ...