However, it has not been clear yet how exactly this protein interacts with its ligands and whether its structure changes depending on the type of molecule being transported. However, it is known ...

Mirkin, who coauthored the paper. "In the small molecule era, it was critical to control the placement of every atom and every bond within a particular structure. If one element was out of place ...

This structure has two helical chains each coiled round the same axis (see diagram). We have made the usual chemical assumptions, namely, that each chain consists of phosphate di-ester groups ...

Chemical insight into biological function is the holy grail of structural biology. Small molecules are central players as building blocks, effectors and probes of macromolecular structure and ...

A molecule named NM102 selectively inhibits the Mfd protein, a bacterial virulence and mutation factor, thereby disarming pathogenic bacteria without affecting beneficial microbiota.

BUTTE, Mont. — The Butte-Silver Bow Fire Department responded to a structure fire on the 200 block of South Washington Street at 11:45 p.m. The fire was quickly controlled and searches of the ...

The intricately folded representation of chemical bonds and atomic arrangements sparked her interest, igniting a profound curiosity about how the structure of molecules influences their function.

In nature and technology, crystallization plays a pivotal role, from forming snowflakes and pharmaceuticals to creating ...

“If I can develop a straight-up inhibitor—[if] I have high conviction I can achieve a chemical structure that’s selective, that has the desired target occupancy, efficacy, and potency ...

This week, learn why experts are divided over an exoplanet, see the first footage of a colossal squid in its deep-sea habitat ...

Neuroscientists have observed for the first time how structures deep in the brain are activated when the brain becomes aware of its own thoughts, known as conscious perception. The brain is ...

One of these drug candidates, AVI-4516, is shown (center) bound to the active site of MPro (surrounding grey structure), where it prevents ... UCSF professor of cellular and molecular pharmacology, co ...