Ukraine struck Russian regions with a major drone and missile attack overnight, damaging at least two factories and forcing schools to close in a major southern Russian city, according to Russian officials and media.

Ukraine has launched its largest attack on Russian military facilities, deploying British Storm Shadow missiles, US-made Atacms missiles and 146 drones to strike targets deep inside Russian territory.

Ukraine's army said Tuesday its missiles struck a Russian chemical factory that makes rocket fuel and ammunition in the Bryansk border region. "Drones successfully distracted Russian air defenses, paving the way for missiles that hit the main targets,

Ukrainian forces used missiles and drones on Tuesday to target sensitive military and energy sites across Russia.

Russia's military on Tuesday said it would retaliate against Ukraine after Kyiv attacked Russian regions by firing six U.S.-made ATACMS ballistic missiles, six UK-made Storm Shadow cruise missiles and launching one of the biggest drone attacks to date.