Leslie Charleson, known for her role as Monica Quartermaine on “General Hospital,” has died. She was 79. Executive producer Frank Valentini announced Charleson’s death Sunday on the show’s Instagram page.

Ms. Charleson played Dr. Monica Quartermaine, a cardiologist and family matriarch, on the daytime series for 46 years.

Leslie Charleson, who played Dr. Monica Bard Webber Quartermaine on General Hospital for over 45 years, has died at the age of 79. The fan favorite played out many memorable storylines over the years — here’s a look back at some of the ABC soap’s best Monica Quartermaine moments.